While CBD oil is generally safe, it is important to be aware of the potential risks involved before you start using it. This includes the possibility of liver damage. In this article, we'll take a look at the evidence surrounding CBD and liver damage to see if you should be concerned. What is CBD? CBD is short for Cann CBD restores liver function according to some studies, but one study has found extreme doses to actually hurt the liver. What’s the truth about CBD oil and liver health? How does the liver respond to regular amounts of CBD? ‘Hopefully it stands up — because otherwise, we’re kind of all owed an explanation for why this was pushed on us.’
Are CBD Gummies Bad For Your Liver?
While CBD oil is generally safe, it is important to be aware of the potential risks involved before you start using it. This includes the possibility of liver damage. In this article, we’ll take a look at the evidence surrounding CBD and liver damage to see if you should be concerned.
What is CBD?
CBD is short for Cannabidiol. It is one of the many compounds found in the cannabis plant. Unlike its more famous cousin, THC, CBD does not produce any psychoactive effects. This means that it won’t make you feel high or intoxicated. Canvast’s Drifter CBN + L-Theanine Gummies are completely THC-free, making them the perfect way to relax stress within the body without any psychoactive effects.
CBD is believed to have a wide range of potential health benefits. These include reducing pain, inflammation, and anxiety. It is also thought to have neuroprotective properties and may be beneficial for treating some neurological disorders.
However, there is still much research to be done on CBD and its potential effects. As such, it is not yet approved by the FDA for any medical conditions.
CBD and Liver Damage
There is some evidence to suggest that CBD could potentially cause liver damage. In one study, rats were given high doses of CBD for seven days. This resulted in increased levels of enzymes that are associated with liver damage.
In another study, mice were given a single dose of CBD (80 mg/kg) or a placebo. After 24 hours, the mice that had received CBD had significantly higher levels of enzymes associated with liver damage.
However, it’s important to keep in mind that these studies were done on animals. There is no evidence to suggest that CBD has the same effect on humans. One human study found that CBD reduced liver damage in people with non-alcoholic fatty liver disease.
Ultimately, an extreme amount, by extreme, we mean a very large amount, of anything can be bad for you. So we advise against consuming absurdly large amounts of CBD, or any other substance for that matter.
As always, it is best to speak with your doctor before starting any new supplement, especially if you have a medical condition or are taking other medications. This is especially important with CBD, as it can interact with some medications.
CBD and Drug Interactions
Another potential risk of taking CBD oil is drug interactions. CBD can interact with some medications, including those used to treat epilepsy. This interaction can lead to increased side effects or make the medication less effective.
It’s also important to note that CBD oil is not regulated by the FDA. This means that there is no guarantee of its purity or potency. As such, it’s important to buy CBD oil from a reputable source.
Should You Be Concerned?
Overall, the evidence suggests that CBD is generally safe and well-tolerated by most people. However, there is a potential for liver damage and drug interactions if you take it in an extreme amount. If you’re considering taking CBD oil, it’s important to talk to your doctor first. They can help you weigh the potential risks and benefits of taking the best CBD oils out there!
So is it safe?
A mouse study published in the summer of 2019 revealed a relationship between CBD and liver damage. Conservatives pushed for a human study like Validcare’s, claiming that the way CBD works in mice differs from how it works in humans and that most individuals would not take the dose of CBD used in the study.
As we said, human studies are ongoing, but the one that has been conducted so far showed promising results.
The study’s findings are certainly excellent news for CBD industry players who may be worried about hefty regulations if the findings had raised red flags.
This means that, as of right now, the answer to whether taking CBD is risk-free is a resounding yes – but be sure to stay up to date in case new information arises!
Types of CBD and its safety
Full-spectrum CBD oil
Full-spectrum CBD oil contains all of the compounds found in the hemp plant, including THC. This type of oil is less processed than isolate or broad-spectrum oils, so it may contain more of the plant’s natural compounds. In addition, full-spectrum oils typically contain other beneficial compounds, such as terpenes and flavonoids.
The THC in full-spectrum CBD oil is what gives it the “entourage effect.” This means that the other compounds in the oil work together to amplify the oil’s effects.
Full-spectrum CBD oil is generally considered to be more effective than isolate or broad-spectrum CBD oil. However, it also has a higher risk of containing trace amounts of THC. While most people tolerate full-spectrum oil well, those who are drug tested or sensitive to THC may want to avoid it.
So, when it comes to safety, full-spectrum CBD oil is likely the best choice. Just be sure to buy it from a reputable source that lab tests its products for potency and purity.
Broad-spectrum CBD oil
Broad-spectrum CBD oil contains all of the compounds found in the hemp plant, except for THC. This type of oil is processed to remove most of the THC, but it may still contain trace amounts.
Broad-spectrum CBD oil is generally considered to be as effective as full-spectrum CBD oil, but it has a lower risk of containing THC. However, it’s important to note that even broad-spectrum oils may contain trace amounts of THC, so those who are drug tested or sensitive to THC should avoid them.
Like full-spectrum CBD oil, broad-spectrum CBD oil is generally considered to be safe.
CBD isolate is the most processed form of CBD. It contains only CBD, without any of the other compounds found in the hemp plant.
CBD isolates are also used to make edibles and topical products.
CBD isolate is generally considered to be safe. However, it’s important to note that CBD isolate is not as effective as full-spectrum or broad-spectrum CBD oil. This is because it doesn’t contain the other beneficial compounds found in the hemp plant.
If you’re considering taking CBD oil, it’s important to talk to your doctor first. They can help you weigh the potential risks and benefits of taking CBD.
CBD is generally safe and well-tolerated by most people, but there is a potential for liver damage and drug interactions if taken in an extreme amount. even if it’s the most processed CBD, you can never be sure what other compounds are added in. So, as with anything, it’s important to start with a low dose and increase gradually as needed.
How many CBD dosage is safe for the liver?
Now onto this meaty question. the maximum safe dosage for CBD has not been established for humans. However, animal studies suggest that taking up to 1500 mg/day of CBD is safe.
While there is no established safe dosage for CBD, most people do not experience any adverse effects from taking it in low to moderate doses.
A common side effect of taking CBD is mild drowsiness. This is generally more pronounced when taking higher doses. If you experience drowsiness after taking CBD, it’s best to take it at night or before bedtime.
CBD can also interact with certain medications, so it’s important to talk to your doctor before taking it if you’re on any medication.
But for the sake of the question, the safe amount of dosage for CBD is 1500 mg/day for humans. The reason behind this is that humans can tolerate up to 1500 mg/day with no adverse effects.
The dosage of CBD is measured in milligrams (mg), and it varies based on the conditions and symptoms you’re attempting to treat, as well as your endocannabinoid system, which is linked to motor control, and cognition, emotions, the neurological system, and homeostasis.
Its dosage is still under research; additional large, high-quality studies in various groups are needed to define acceptable dosing, efficacy, and safety guidelines.
So speaking of symptoms you’re trying to treat, let’s get into how much CBD you should take for different purposes.
CBD for anxiety
The standard dose of CBD for anxiety is 25 mg/day. This can be increased to a maximum of 300 mg/day if needed. Study shows that CBD is effective in treating anxiety, but only at doses of 300 mg/day or less. This means that higher doses are not necessarily more effective and can incur overdose.
Remember that symptom of anxiety-like racing thoughts, sweating, and a pounding heart can also be symptoms of other conditions like a heart attack. So if you’re experiencing these symptoms, it’s important to see a doctor to rule out any other potential causes.
However, CBD can alleviate these symptoms without the risk of overdose, if you take it lightly, of course!
CBD for pain
When it comes to finding the right CBD for pain, there is no one-size-fits-all answer. The ideal dosage will vary depending on several factors, including the severity of the pain, the type of pain, and the person’s physiology.
That said, some general guidelines can help people find the right starting point.
For instance, most experts recommend beginning with a low dose and gradually increasing it until the desired effect is achieved. Additionally, it is important to start slow and increase gradually to avoid any unpleasant side effects.
Finally, it is always best to consult with a doctor or other healthcare professional before beginning any new supplement regimen.
but as a rule of thumb, the general dosage of CBD for pain is 25 mg/day. This can be increased to a maximum of 300 mg/day if needed.
CBD for sleep
The National Sleep Foundation reports that 60 million Americans suffer from insomnia. CBD is a non-psychoactive compound found in cannabis that is known to have therapeutic properties. A recent study published in The Permanente Journal looked at the effect of CBD on 72 adults with anxiety and poor sleep.
The study found that 25mg of CBD given daily helped to improve sleep quality and reduce anxiety levels. While more research needs to be done to determine the optimum CBD dosage for sleep, the study shows that CBD can be an effective natural treatment for insomnia.
If you are considering using CBD to improve your sleep, it is important to consult with a medical professional to ensure that it is safe for you.
CBD effects on the liver
In a 2019 animal study, CBD increased cellular activity, indicating liver injury. The dosage of CBD remained high indicating the most dosage when consuming CBD for epilepsy. There are currently no known results from human livers taken with Epidiolex since its development is very early. However, there’s no doubt that CBD and liver are incompatible. A recent study showed that low concentrations of CBD are effective to inhibit alcohol in rats and a mouse liver.
But how do you even take CBD oil?
Okay, now that we’ve gone over the different dosages of CBD, let’s talk about how to take it.
CBD oil can be taken in a variety of ways. It can be ingested, inhaled, or applied topically. The best method of administration will depend on the person’s individual needs and preferences.
For instance, those who are looking for immediate relief may prefer to inhale CBD oil through a vape pen. Those who are concerned about the psychoactive effects of THC may prefer to use a CBD tincture, which contains little to no THC.
And those who are interested in using CBD for skin care may prefer to apply it topically in the form of a cream or lotion.
Finally, it is important to remember that CBD oil is not regulated by the FDA. This means that there are no official guidelines on how to take it. As such, it is always best to start with a low dose and increase gradually as needed.
Enter CBD Gummies!
These edibles are made with CBD oil that has been extracted from hemp plants. They are then infused into gummy bear-shaped candies.
CBD Gummies are a great option for those who want to take CBD conveniently and deliciously. They are also a good choice for those who are concerned about the psychoactive effects of THC.
CBD Gummies are available in a variety of different dosages. This makes them a good option for those who want to be able to control their dose of CBD.
The downside of CBD Gummies is that they can be more expensive than other forms of CBD. Additionally, they may contain added sugar and other ingredients that some people may not want to consume.
But who doesn’t want a tinge of sweetness?!
Effect of CBD Gummies good on the liver?
CBD Gummies are not known to have any negative effects on the liver. CBD is known to be protective of the liver. A study published in the Journal of Gastroenterology found that CBD was able to reduce the inflammatory response in the liver and promote cell regeneration.
Another study, this one published in Frontiers in Pharmacology, found that CBD was able to protect against alcohol-induced liver damage.
These studies suggest that CBD may be a helpful treatment for those who suffer from liver disease. However, more research is needed to confirm these results.
The gummy form or candy edible form of these CBD makes it easy to digest and helps with the absorption process. When it comes to taking CBD and how it will affect your body, always remember to start with a low dose and increase gradually as needed. We also recommend that you consult with a medical professional before beginning any new supplement regimen.
CBD effects on the liver
To give you the full story, we need to take a step back and look at how CBD is metabolized in the body.
CBD is metabolized by the liver. This means that it is broken down by enzymes in the liver before it can enter the bloodstream.
The liver is responsible for filtering toxins out of the blood. It also regulates metabolism and breaks down nutrients so that they can be used by the body.
When CBD is metabolized by the liver, it is broken down into smaller molecules. These molecules are then able to pass through the blood-brain barrier and interact with receptors in the brain.
In layman’s terms, this means that when you take CBD, it is metabolized by the liver and then passed into the bloodstream where it can interact with the brain.
Below are some of the expected effects of CBD on the liver:
CBD restores liver function
The liver is responsible for filtering toxins from the blood, and when it becomes damaged, it can no longer perform its essential functions. CBD oil helps to protect the liver from damage and improves its ability to filter toxins from the blood. In addition, CBD oil helps to reduce inflammation and promote cell regeneration, both of which are essential for restoring liver function. As a result, CBD oil may be an effective treatment for those with liver damage or disease.
CBD protects against alcohol-induced liver damage
CBD oil is made by extracting CBD from the cannabis plant and then diluting it with a carrier oil such as coconut oil or hemp seed oil. Early research suggests that taking CBD might improve liver function in people with non-alcoholic fatty liver disease (NAFLD). In a small study, participants with NAFLD who took CBD had reduced levels of fat in their liver and improved blood sugar control. CBD may also help reduce inflammation, which is a key contributor to the development of NAFLD. In addition, CBD has been shown to protect against cell damage and improve overall liver function. While more research is needed, these early findings suggest that CBD could be an effective treatment for NAFLD.
CBD improves metabolism
A new study has found that CBD may help to promote weight loss by reducing food consumption and increasing metabolism. CBD is a compound found in cannabis plants, and while it has been shown to have numerous health benefits, its effects on weight have been less well-studied. However, previous research has suggested that CBD may help to reduce appetite and promote metabolism. The new study, which was conducted on rats, found that CBD influences weight by interacting with CB1 and CB2 receptors in the lymphoid tissue and the brain. The rats that were given CBD ate less food and gained less weight than the rats that were not given CBD. The results of this study suggest that CBD may be an effective obesity treatment.
Side effects of CBD
According to a recent report, CBD carries a good safety profile. Many people choose CBD to reduce the risk of liver diseases. It has relatively low side effects if taken at large concentrations, notably the presence of THC and the use of marijuana as an alternative for smoking. Taking high-grade CBD oils daily is unlikely to cause side effects.
According to a recent report, CBD carries a good safety profile. Many people choose CBD to reduce the risk of liver diseases. It has relatively low side effects if taken at large concentrations, notably the presence of THC and the use of marijuana as an alternative for smoking. Taking high-grade CBD oils daily is unlikely to cause side effects.
But to be on the safe side, if you are new to CBD, start with low doses and increase gradually. You should also consult your doctor before starting to take CBD, especially if you are taking any medications.
CBD can interact with some medications, so it is important to check with your doctor before taking it.
Possible side effects of CBD include:
Dry mouth is a common side effect of CBD, this is because CBD reduces the production of saliva. To combat this, drink plenty of water and chew sugar-free gum or mints to keep your mouth moist.
CBD may cause drowsiness in some people, especially at high doses. If you experience drowsiness after taking CBD, it is best to stay well-hydrated and avoid driving or operating heavy machinery.
Diarrhea is another common side effect of CBD, this is because CBD can act as a laxative. If you experience diarrhea after taking CBD, be sure to stay hydrated and drink plenty of fluids.
Interactions with medications
As mentioned above, CBD can interact with some medications. If you are taking any medications, it is best to consult with your doctor before taking CBD.
Possible drug interactions include:
CBD and grapefruit
CBD and grapefruit juice may interact with each other. Grapefruit inhibits the activity of CYP3A4, an enzyme that metabolizes many drugs. CBD also inhibits the activity of this enzyme. As a result, taking CBD and grapefruit together may increase the levels of CBD in your blood. This could increase the effects and side effects of CBD. To avoid this interaction, do not drink grapefruit juice while taking CBD.
CBD and other medications that are metabolized by CYP3A4
As mentioned above, CBD can inhibit the activity of CYP3A4, an enzyme that metabolizes many drugs. This could increase the levels of those medications in your blood. To avoid this interaction, do not take CBD if you are taking any medications that are metabolized by CYP3A4.
CBD and warfarin
CBD may increase the levels of warfarin in your blood. Warfarin is a medication that prevents blood clots. Taking CBD and warfarin together may increase the risk of bleeding. To avoid this interaction, do not take CBD if you are taking warfarin.
CBD and other medications that affect blood clotting
As mentioned above, CBD may increase the levels of warfarin in your blood. Warfarin is a medication that prevents blood clots. Taking CBD and warfarin together may increase the risk of bleeding. To avoid this interaction, do not take CBD if you are taking any medications that affect blood clotting.
CBD and medications for anxiety
CBD may increase the effects of some medications used for anxiety, such as benzodiazepines. Benzodiazepines are a type of medication that is used to treat anxiety and sleep disorders. Taking CBD and benzodiazepines together may increase the risk of drowsiness and sedation. To avoid this interaction, do not take CBD if you are taking any medications for anxiety.
CBD and other sedatives
As mentioned above, CBD may increase the effects of some sedatives, such as benzodiazepines. Taking CBD and benzodiazepines together may increase the risk of drowsiness and sedation. To avoid this interaction, do not take CBD if you are taking any sedatives.
CBD and medications for sleep
CBD may increase the effects of some medications used for sleep, such as benzodiazepines. Taking CBD and benzodiazepines together may increase the risk of drowsiness and sedation. To avoid this interaction, do not take CBD if you are taking any medications for sleep.
Does CBD oil increase liver enzymes?
This is yet another question that we get asked a lot. The answer, however, is a little bit more complicated than simply yes or no. CBD may increase liver enzymes in some people, but it does not do so in all people.
Cannabidiol (CBD) is a non-intoxicating compound of the cannabis plant that has gained popularity in recent years for its potential therapeutic benefits. Though CBD oil is typically well-tolerated, it can cause some side effects, including headaches, dizziness, dry mouth, and changes in appetite. Some people also report an increase in liver enzymes after taking CBD oil.
Liver enzymes are proteins that help to speed up chemical reactions in the liver. They are normally present in small amounts in the blood. However, if the liver is damaged or inflamed, these enzymes can leak into the bloodstream and cause problems.
In most cases, elevated liver enzymes are not a cause for concern and will return to normal levels on their own. However, in rare cases, they may be a sign of more serious liver damage. If you experience an increase in liver enzymes after taking CBD oil, it is important to talk to your doctor to rule out any underlying causes.
It all boils down to this; if you are taking CBD oil and your liver enzymes begin to rise, it is important to contact your doctor to rule out any possible underlying causes. In the vast majority of cases, however, elevated liver enzymes are not a cause for concern and will return to normal levels on their own.
Is CBD affecting your liver? The opinion of experts
The market to use products with cannabinoids — the nonpsychoactive pain-reliever molecule that makes cannabis — has exploded over recent years, but its effectiveness remains fairly unstudied. The FDA is also considering deciding whether to approve the CBD supplement, but it is not based on science. In the aforementioned animal research, the researchers discovered over the past few days the effects of CBD on liver damage can be severe and even deadly in high dosages. In this last portion of the article, we reviewed the studies of experts on its potential effects on humans who enjoy CBD.
What the research says
Researchers from the University of Arkansas evaluated the effects of various dosages of CBD on a group of 8-week-old mice, citing a “paucity of thorough toxicological studies devoted to CBD safety that are crucial for continued commercialization of CBD and CBD-containing products.”
The mice tolerated the CBD well, but those given the highest doses – 200 mg of CBD per kilogram of body weight in humans — exhibited strong evidence of liver toxicity, according to the researchers.
This means that CBD might potentially be damaging to the liver in large doses, and more research needs to be done to determine the long-term effects of CBD on the human liver.
That’s why it’s important to be mindful of the doses you’re taking and to start with a low dose if you’re new to CBD. If you have any concerns about its effects on your liver, be sure to speak with your doctor before starting to use CBD.
The above research might be worrisome but it actually shouldn’t be. CBD has a wide therapeutic margin, meaning that it can be taken in high doses without causing any serious side effects. One study showed that dosages of up to 1,500 mg per day were well-tolerated by human subjects.
So, if you’re concerned about the potential effects of CBD on your liver, don’t worry! You would have to take extremely high doses for it to cause any damage.
While experts agree that patients should be aware of what they’re getting and the potential hazards, the amount of CBD the animals were exposed to was significantly more than what most people would take.
Even though CBD is widely available, says Dr. Diana Martins-Welch, an attending physician in palliative at Northwell Health in New Hyde Park, New York, “it does not mean it is safe to consume in large amounts, or that it is more beneficial at high dosages.”
“Many individuals are aware that taking too much ibuprofen or Tylenol might be harmful. CBD is no exception. Therapeutic CBD doses typically vary from 0.5 mg/kg/day to 20 mg/kg/day, according to Martins-Welch.
So stick to the right dosage!
CBD is a powerful compound with a wide range of therapeutic properties. However, it’s important to stick to the right dosage to avoid any potential risks.
Because many CBD products sold over-the-counter are not regulated by the federal government, you may be taking more or less of the chemical than is stated on the label.
The FDA has issued a flurry of warning letters in recent years as a result of CBD products being sold with either erroneous quantities of the compound that didn’t fit what was indicated on the box or trace concentrations of THC, cannabis’ psychotropic chemical and a Schedule 1 narcotic.
This means you have to be careful about what you’re buying!
Although the dosage of CBD you take is important, it’s also important to be mindful of the quality of the product you’re using.
We talked about how CBD gummies and other CBD products can help improve your sleep, mood, and pain levels. As we said, CBD gummies, in their edible nature, are easier to digest and have a more relaxing effect on the body.
It also has many flavors, which can be helpful if you have a sensitive stomach. If you want to try CBD but are worried about its effects on your liver, start with a low dose and increase gradually as needed.
And finally, be sure to buy your CBD products from a reputable source to ensure that you’re getting a quality product.
Most importantly, don’t forget that you should always speak with your doctor before starting to use CBD, especially if you have any concerns about its potential effects on your liver.
We hope you found this article helpful! Thanks for reading! Visit Canvast online or in-store to shop our premium cannabis edibles, like our Drifter CBN + L-Theanine Gummies or our Shifter Delta-9 + Electrolytes!
CBD and Liver Damage: How Does It Affect Liver Functions?
As the use of CBD is booming across the United States, people have become more aware of its health benefits as well as potential risks associated with the consumption of CBD products.
One recent study has sparked concerns among CBD users when it comes to liver function. While the study did show that extremely large amounts of CBD can damage the liver, the news coverage that warned about the potential risk of taking CBD failed to put the study into context.
It goes without saying that CBD — like any supplement or medication — does have side effects, including dose-dependent danger to liver health. However, while users using the peak-tested dosages should have their liver enzymes in check, the vast majority of people can safely use CBD without worrying about a negative impact on their liver function.
In this article, we’ll explain the context of the said study and provide evidence supporting the health benefits of regular doses of CBD for liver health.
Let’s resolve the doubts surrounding the topic of CBD and liver function.
Is CBD Oil Bad for Your Liver?
CBD has a remarkably good safety profile. Researchers have tested the efficacy and safety of CBD in humans using doses as high as 1,500 mg – 3000 mg CBD daily.
With 1,500 mg of CBD taken for a six-week period, no dangerous side effects were observed (1).
However, the recent 2019 study on mice showed that high doses of CBD can damage the liver — causing widespread sensation all over the media.
The study has also garnered attention among CBD skeptics who have been trying to undermine the therapeutic potential of CBD looking for at least one serious side effect.
Now, we’re not saying CBD doesn’t have any side effects — it does, like any other health supplement — but should you actually worry about your liver when you use normal doses?
Let’s shed some light on the infamous study on mice.
The Study on CBD and the Liver of Mice
According to researchers from the University of Arkansas, who investigated the effects of treatments of various doses of CBD on a group of 8-week-old mice, the study addressed the problem of a “lack of comprehensive toxicological studies devoted to CBD safety that are critical for further marketing of CBD and CBD-containing products.” (2)
The majority of mice tolerated the CBD, but those administered the highest doses — an equivalent to 200 mg of CBD in humans — showed clear symptoms of liver toxicity, as reported by the researchers.
In addition, repeated doses of a smaller amount of CBD (50 mg) also showed signs of liver damage and swelling.
Here’s what the authors wrote at the end of the paper:
“Although (a dose of) 200 mg is not applicable to most real-life scenarios, it does provide critical information regarding the potential consequences of CBD overdose as well as for doses needed for further subchronic and chronic toxicity studies.”
However, one of the caveats of this study was that it tested the maximum recommended daily dosage for humans. While all mammals share the same endocannabinoid system, mice and humans are different physiologically. The size of the liver is just one of the many variables that should be taken into consideration when evaluating the safety of CBD in human subjects.
Experts Say It’s About the Dosage
Although the results of the above study sound potentially discouraging, most experts say there’s no need to freak out over the impact of CBD on the liver. While experts stress the importance of knowing the risks of taking health supplements, the amount of CBD the mice were exposed to is much higher than what most humans take.
According to Dr. Diana Martins-Welch, attending physician in palliative medicine at Northwell Health in New Hyde Park, New York, there are certain quantities in which CBD may not be safe for humans; CBD also isn’t always more effective in high doses.
“Many people know that taking too much ibuprofen or Tylenol can have detrimental consequences. CBD is no different. Generally speaking, therapeutic CBD doses range from 0.5 mg/kg/day to 20 mg/kg per day. This study in mice used significantly higher doses of CBD (in relation to their weight) than what is usually taken for therapeutic benefit in humans.” Martins-Welch explained.
Martins-Welch also said that therapeutic-range CBD is generally safe, and while toxicity at extremely high doses is a concern, it is no different than with other supplements or medicines.
Therefore, what the study essentially showed was how people need to be careful if they take high doses of CBD daily.
Human studies that have examined the safety of different doses of CBD have found no negative effects at the recommended maximum daily dosage of 20 mg/kg. This dosage was taken from the trial of Epidiolex, a CBD-based pharmaceutical for treatment-resistant seizures. To put that in context, an individual weighing 150 pounds would need to take over 1,300 mg of CBD per day, which is way above what most people take (10–80 mg daily).
Effects of CBD On the Liver
Okay, so now you know that extremely high doses of CBD may cause liver toxicity when taken regularly. You also know that it’s impossible to trigger toxicity with normal doses of CBD oil.
Now it’s time to ask a different question: what positive effects does CBD have on the liver?
There are plenty, to be honest.
In the next section, we elaborate on the potential therapeutic uses of CBD oil for liver function.
CBD Oil for Fatty Liver
The endocannabinoid system (ECS) is found in all mammals and consists of receptors (CB1 and CB2) endogenous cannabinoids, and enzymes that facilitate their production or break them down.
The ECS is responsible for regulating many of our homeostatic control processes. In other words, this network controls the balance of various systems and organs in the body, including the liver.
When the liver gets damaged, inflamed, or dysfunctional, the body starts to release more endocannabinoids to solve the problem. A healthy liver is correlated with a modest activity of the endocannabinoid system. In fact, this particular organ has a relatively low concentration of the ECS components.
However, inflammation in the liver causes the endocannabinoid to be very active in this area. Unfortunately, an overactive endocannabinoid system plays a role in the development of fatty liver disease (3).
CBD is the modulator of CB1 and CB2 receptors. In simple English, it keeps them from going crazy by stopping the compounds that make these receptors go haywire in the liver.
CBD ensures the proper functioning of a system that balances us. So while it won’t cure fatty liver disease, it can prevent its development. And should the disease occur, it may be able to reduce the inflammation in the organ, protecting it against further damage.
CBD Oil for Liver Cancer
To this day, studies on cannabinoids and their effect on liver cancer show that cannabinoids can both prevent the dividing of tumor cells and kill cancer cells while protecting the healthy ones. Besides stopping cancer proliferation, there are several mechanisms CBD uses to help tackle liver cancer.
First, it provides anti-metastatic actions, preventing distant tumor masses from forming in the liver.
Second, it prevents the formation of blood vessels that facilitate tumor growth.
And last but not least, CBD triggers apoptosis, which is programmed cell death. Researchers have found this ability during animal and laboratory models; these properties apply to both CBD and THC (4).
Although no study has yet analyzed the effects of CBD on liver cancer in humans, current research supports the use of cannabinoids as a complementary therapy as well as a means of reducing the side-effects of chemotherapy and radiation.
CBD Oil for Viral Hepatitis
Viral hepatitis is one of the most common infectious diseases characterized by inflammation. It is also a great contributor to many deaths globally. Hepatitis can lead to the formation of liver cancer and cirrhosis.
CBD has been shown to have therapeutic effects on the models of viral hepatitis, especially Hepatitis C. According to a study published in the journal Pharmacognosy Research, CBD was shown to inhibit the replication of hepatitis C virus by almost 90% (5).
The inhibitory effects on the virus were dose-dependent but showed little toxicity towards the cells. CBD was also found to induce death in the infected cells containing the hepatitis B virus, although it did not inhibit the virus itself.
Finally, the attenuation of the immune response through the interaction with the ECS in the immune cells may help in alleviating autoimmune hepatitis.
CBD Oil for Hepatic Ischemia
Ischemia is a very common injury that occurs as an aftermath of liver surgeries and liver transplantations. It involves major inflammation and is responsible for deaths in the case of transplants and rejections. Oxidative stress can worsen the condition.
CBD is known for its anti-inflammatory and antioxidative properties, so it could be useful in reducing the inflammatory response and protecting the liver against oxidative damage. In experimental models, CBD effectively reduced inflammation, oxidative stress, and promoted the death of malignant cells in the liver.
Other studies found that administration of CBD to the rats with ischemic liver injury resulted in a significant reduction of liver damage associated with the condition (6).
CBD Oil for Hepatic Encephalopathy
Hepatic encephalopathy is characterized by psychological changes resulting from the damage and failure of the liver. Some symptoms include altered personality, confusion, movement problems, etc. It can lead to a coma in severe cases.
Inflammation is one of the main causes of hepatic encephalopathy. A study conducted on mice models of hepatic encephalopathy reported positive effects. The research team observed that applying CBD to mice could restore the neurological functions and cognitive performance in the mice. CBD also reduced the levels of ammonia in the blood, helping restore liver function and normalize the number of liver enzymes (7).
CBD Oil for Autoimmune Hepatitis
Autoimmune hepatitis results from a weakened immune system that attacks the liver. Again, inflammation is the key player in the development of this disease. One study has reported that the activation of TRPV1 vanilloid receptor — part of the ECS — lowers inflammation by activating myeloid-derived suppressor cells (MDSCs). These cells, in turn, block inflammation and the development of autoimmune hepatitis.
CBD happens to activate the TRPV1 receptors, not only reducing the pain but also inhibiting the proliferation of T cells that trigger inflammation (8). Therefore, it’s within reason to assume that CBD could be used for the prevention and treatment of liver inflammation and autoimmune hepatitis.
CBD Oil for Alcohol-Induced Liver Injury
Liver fibrosis is a common result of chronic liver damage caused by binge drinking. It can lead to cirrhosis and liver failure.
CBD has been shown to have anti-fibrosis properties by eliminating cells that secrete collagen and cause fibrosis. It can also reverse alterations in the liver associated with alcohol-induced injury (9).
Does CBD Oil Increase Liver Enzymes?
The studies performed on how CBD affects liver function have brought conflicting results.
For example, one study found that 10% of the subjects had higher levels of liver enzymes and had to stop using CBD for this reason. Other studies suggest that CBD can improve liver function. Since CBD is metabolized by the liver — as shown by the studies done on Epidiolex — patients with liver diseases should limit over-the-counter (OTC) medications to avoid potential CBD-drug interactions and reduce the stress experienced by the liver.
Long story short, CBD is generally safe for your liver enzymes if you don’t exceed the dose of 20 mg CBD/kg/day.
CBD Dosage for Liver
If you’re looking to improve liver function with CBD oil, you’re probably wondering how much CBD is enough to provide relief from pain and inflammation and to keep this organ healthy.
Unfortunately, there are no official dosage recommendations when it comes to CBD and the liver. Most clinical trials that suggest specific dosages of CBD have been performed on anxiety, chronic disorder such as epilepsy, and multiple sclerosis models in humans. No clinical study has yet investigated the efficacy of different doses of CBD on the symptoms of liver disease.
The optimal amount of CBD for each individual depends on factors such as weight, metabolism, age, gender, the severity of symptoms, and previous history with CBD products.
The best approach you can take is to start low and gradually increase the dose until you experience the desired relief. We suggest that you start with 5–10 mg CBD and try it out for one week, monitoring the effects. If you deem the dose insufficient, add another 5 milligrams and continue for another week, reassessing the results.
We also encourage you to consult a doctor knowledgeable about CBD and cannabis in general. A qualified physician should help you avoid potential interactions with other medications and determine the right dosage range.
Side Effects of CBD
As mentioned earlier in the article, CBD has an excellent safety profile. People turn to CBD because it’s a low-risk alternative to conventional treatment options for liver disease. That being said, it has a few relatively mild effects when consumed in high doses, including:
- Dry mouth
- Changes in appetite
Some of these side effects may result from consuming a mislabeled product that has more than 0.3% THC, or one that has been sourced from poor-quality hemp or extracted with aggressive solvents. When you take high-quality CBD oil at regular doses, the above side effects are nearly non-existent.
However, there’s a risk of potential drug interactions, as CBD is metabolized by the same group of enzymes that process active ingredients in pharmaceuticals. As an inhibitor of those enzymes, CBD can lead to either subtherapeutic effects or substance toxicity when taken along with medications for liver function. That’s why we recommend consulting a doctor before adding CBD oil to your routine.
CBD Oil and Liver: Bottom Line
The liver is a fundamental detoxifying organ that performs many important functions to keep the body in the optimum state. It plays a role in digestion, detoxification, drug metabolism, and more.
There are many diseases affecting the liver as it is constantly exposed to environmental damage from pollutants, alcohol, drugs, medications, etc. It is also prone to autoimmune diseases.
CBD has been shown to have therapeutic effects in many major liver diseases, including viral hepatitis, fatty liver disease, ischemia-reperfusion injury, cirrhosis, fibrosis, and liver cancer.
High-quality full-spectrum CBD oil could be beneficial in a range of disorders that involve liver dysfunction and might help replace the long-term use of other medications.
Although extremely high doses of CBD taken daily have been associated with liver toxicity, so have other supplements and medications. Therefore, it’s best to keep your use of CBD within reason. Doses as high as 20 mg of CBD per kg don’t pose a threat to your liver’s health, as tested in the clinical trial of Epidiolex, a CBD-based anti-seizure medication.
Patients should seek medical consultation before incorporating CBD into their routine to discuss the dosage and establish the right time schedule to avoid potential interactions with other medications.
- Iffland, Kerstin, and Franjo Grotenhermen. “An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies.” Cannabis and cannabinoid research vol. 2,1 139-154. 1 Jun. 2017, doi:10.1089/can.2016.0034
- Ewing, Laura E et al. “Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.” Molecules (Basel, Switzerland)vol. 24,9 1694. 30 Apr. 2019, doi:10.3390/molecules24091694
- Purohit, Vishnudutt et al. “Role of cannabinoids in the development of fatty liver (steatosis).” The AAPS journal vol. 12,2 (2010): 233-7. doi:10.1208/s12248-010-9178-0
- Vara, D et al. “Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy.” Cell death and differentiation vol. 18,7 (2011): 1099-111. doi:10.1038/cdd.2011.32
- Lowe, Henry I C et al. “Potential of Cannabidiol for the Treatment of Viral Hepatitis.” Pharmacognosy research vol. 9,1 (2017): 116-118. doi:10.4103/0974-8490.199780
- Fouad, Amr A, and Iyad Jresat. “Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats.” European journal of pharmacology vol. 670,1 (2011): 216-23. doi:10.1016/j.ejphar.2011.08.048
- Avraham, Y et al. “Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice.” British journal of pharmacology vol. 162,7 (2011): 1650-8. doi:10.1111/j.1476-5381.2010.01179.x
- Muller, Chanté et al. “Cannabinoid Ligands Targeting TRP Channels.” Frontiers in molecular neuroscience vol. 11 487. 15 Jan. 2019, doi:10.3389/fnmol.2018.00487
- Zurier, Robert B, and Sumner H Burstein. “Cannabinoids, inflammation, and fibrosis.” FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 30,11 (2016): 3682-3689. doi:10.1096/fj.201600646R
Livvy is a registered nurse (RN) and board-certified nurse midwife (CNM) in the state of New Jersey. After giving birth to her newborn daughter, Livvy stepped down from her full-time position at the Children’s Hospital of New Jersey. This gave her the opportunity to spend more time writing articles on all topics related to pregnancy and prenatal care.
64 million Americans have tried CBD and now the FDA says it could cause liver damage
‘Hopefully it stands up — because otherwise, we’re kind of all owed an explanation for why this was pushed on us’
The FDA issued a warning to consumers about potential health effects from CBD, including liver damage.
- Email icon
- Facebook icon
- Twitter icon
- Linkedin icon
- Flipboard icon
- Print icon
- Resize icon
Brandon Warne, a Minnesota Twins beat reporter for the sports news outlet Zone Coverage, started taking cannabidiol (CBD) in August after growing increasingly frustrated with his depression and anxiety medications over the past four years.
“I was just at a point where nothing was working for me,” Warne, 33, of Minnesota’s Twin Cities area, told MarketWatch. “I was just trying to branch out because I was just so upset [and] distraught with my lack of progress towards mental health.”
Under the guidance of his psychiatrist and therapist, Warne started taking CBD and pared down his medication list. He tapered off the antidepressants bupropion GSK, +1.21% and Effexor PFE, +1.61% , but continued to take his anti-anxiety medication, buspirone TEVA, +1.89% , after experiencing “wicked side effects” from trying to go off of it. He now takes CBD in the form of a 0.5-ml dose of Clean Remedies full-spectrum hemp extract oil every morning, and plans to eventually try to taper the buspirone as well.
Warne, who received his diagnoses after his grandfather’s death, wonders whether he was misdiagnosed. But the results he has seen since taking CBD, he said, have been “moderately positive.” “I’ve been feeling great since I got off my meds,” he said.
“ ‘We remain concerned that some people wrongly think that the myriad of CBD products on the market, many of which are illegal, have been evaluated by the FDA and determined to be safe, or that trying CBD ‘can’t hurt.’ ”
— — Amy Abernethy, FDA principal deputy commissioner
Warne isn’t entirely sure whether it’s the CBD oil or being off his meds that’s causing the improvement, but he is willing to continue trying CBD when he’s done with his current bottle. He said he still has “research” to do on the matter — and a new FDA warning backs him up.
The Food and Drug Administration said late Monday that what you don’t know about CBD might hurt you and warned that it could cause serious health problems, including liver damage.
The warning comes as millions of consumers have jumped on board with the non-psychoactive cannabis compound for reasons relating to health, wellness and recreation, and CBD has popped up on restaurant menus, in post-workout salves and in bath bombs.
The FDA sent letters warning 15 companies for illegally selling CBD-containing products. The federal agency also updated its position to clarify that the substance increasingly infused in pills, lotions, food products and wellness beverages “has the potential to harm you, and harm can happen even before you become aware of it.”
“We remain concerned that some people wrongly think that the myriad of CBD products on the market, many of which are illegal, have been evaluated by the FDA and determined to be safe, or that trying CBD ‘can’t hurt,’” Amy Abernethy, the FDA’s principal deputy commissioner, said in a statement.
The only CBD product approved by the FDA is the prescription drug Epidiolex, which treats pediatric epilepsy. It’s illegal to market CBD as a dietary supplement.
The compound can cause liver injury, interact with other drugs, and increase the risk of drowsiness and sedation when used with alcohol, the FDA said. Studies using lab animals have also shown negative impacts on the male reproductive system, though the takeaway for human patients remains unclear, the FDA said.
The agency also provided a list of potential side effects related to CBD, including sleepiness, diarrhea and/or a decrease in appetite, and mood changes such as agitation and irritability.
Many questions, not many answers
Scientists still don’t know what happens if a person consumes CBD daily for sustained time periods; the compound’s effect on children who take CBD, growing fetuses or breastfed newborns; its interactions with herbs and botanicals; and whether it leads to the same male reproductive problems in men as observed in animals, the FDA said.
What’s more, the FDA is concerned about “a lack of appropriate processing controls and practices”: Many products tested by the FDA have contained different CBD levels than what manufacturers claimed, and there have been reports of products containing unsafe levels of pesticides, heavy metals and THC, the agency said.
“I still don’t think it’s so harmful that I shouldn’t use what I have,” Warne said in response to the new FDA warning. “But it certainly makes me question how settled the science is … and maybe it’s not as ironclad as I thought it was before.”
64 million Americans have tried CBD
Research published this year by the consumer-data firm MRI-Simmons estimated that 3.7 million U.S. adults were CBD consumers, with a median age of 45. Even more appear to have dabbled in the substance: Some 64 million Americans — 26% of the country — report having tried CBD in the last two years, according to a nationally representative Consumer Reports survey of more than 4,000 people conducted in January. One in seven of those respondents reported daily use.
And many CBD users use the compound for its health potential, though their outcomes tend to be mixed.
More than a third of respondents to the Consumer Reports survey said they used CBD to reduce stress or anxiety or promote relaxation; 63% of those people said the compound was “extremely or very effective” at doing so, while 16% said it was not at all or only slightly effective. Nearly one in four respondents said they used CBD to help with joint pain, with 38% calling it “extremely or very effective” and 27% saying it was slightly or not at all effective.
The Mayo Clinic says that “although some research appears to indicate that CBD might hold benefit for treating anxiety-related disorders, more study is needed.” And physician Peter Grinspoon, writing on the Harvard Health Blog, noted that an animal study had shown that applying CBD to the skin could help lower arthritis-related pain and inflammation. “More study in humans is needed in this area to substantiate the claims of CBD proponents about pain control,” he added.
Warne is not alone in using CBD to replace or supplement a medication: 30% of respondents to the Consumer Reports survey said they had taken CBD in addition to a prescription or over-the-counter medication, while 22% said they replaced the medication with CBD entirely. A third of those who replaced a medication with CBD said that the drug was a prescription anti-anxiety drug.
Still, Warne called the FDA’s words of caution “prudent” and agreed that more research should be conducted on CBD’s benefits and risks.
“Hopefully it stands up — because otherwise, we’re kind of all owed an explanation for why this was pushed on us for the past year or however long this has been popular,” he said. “Hopefully we get an explanation one way or the other.”