Can I Give My Dog Rimadyl And CBD Oil


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Carprofen and cbd interaction possible side effects and benefits. How to substitute one another in some cases Overall, CBD use in dogs appears to have a good safety profile and is at low risk for side effects. But “Appears” is the key word here.

Carprofen and CBD Interaction: Possible Side Effects

Carprofen is not a new drug and has been around since 1996 under brand name Rimadil. It’s a steroid-free narcotic drug which pet owners use for treating inflammation caused by osteoarthritis. In addition, vets prescribe this medication for pain management for pets after surgeries. You can find Carprofen by other brand names:

Acticarp, Austiofen, Bomazeal, Canidryl, Carporal, Carprieve, Carprocow, Carprodolor, Carprodyl, Carprofelican, Carprofen, Carprofène, Carprofeno, Carprofenum, Carprogesic, Carprosol, Carprotab, Carprox, Comforion, Dolagis, Dolocarp, Dolox, Eurofen, Kelaprofen, Librevia, Norocarp, Norodyl, Novocox, Prolet, Reproval, Rimadyl, Rimifin, Rofeniflex, Rycarfa, Scanodyl, Tergive, Vetprofen, and Xelcor.

How Does It Work?

Carprofen may inhibit special enzymes called COX2, which are part of the inflammation process in the body. In other words, the medication prevents this enzyme from working properly and as a result, prevents inflammation itself.

Depending on the severity of inflammation, the usual dosage is 2 to 4 mg per kg of the pets body weight. It can be taken once daily as a single dose or twice a day.

Side Effects

According to the FDA page, not all side effects can be predicted. Therapy with Carprofen can unmask some hidden health issues such as kidney disease or liver dysfunction. Some of the side effects may include:

  • Diarrhea
  • Vomiting
  • Seizures
  • Loss of Appetite
  • Increased Thirst
  • Increased Urination
  • Loss of Coordination
  • Fatigue
  • Lethargy
  • Skin Changes
  • Paralysis
  • Change in Behavior

Most of the vets start with a lower dosage to make sure the dog reacts well to the medication.

CBD: What it is?

As we mentioned before in Best CBD Products for Pets and How to Choose Them, “Isolate is the purest form CBD which has no other ingredients from the hemp plant. Isolate contains 99% pure CBD in it which is considered the most healing component for the body.

There is no risk of getting intoxicated or “high” and is safe for all types of CBD users. It’s odourless and has no flavour so it can be perfect for you and a pet.”

How Does it Work?

It’s very interesting that scientists didn’t know much about CBD and how it interacts with our body until recently. They discovered that humans and animals have an endocannabinoid system. This system is a chain of special receptors (CB1 and CB2) that are spread all over the living body. You can find them in the lungs, skin, abdomen, bones, in the neuro system, reproductive system and also vascular system.

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CBD as a natural component can interact with these receptors and help the endocannabinoid system work better and more efficiently. In simple words, CBD has a natural power to help our body and mind live in balance and health.

Side Effects

After numerous CBD benefits, scientists started to research the side effects of CBD oil as well. They found no evidence of CBD being addictive and or unsafe for people or animals to use. What they found is that an unregulated dosage of CBD can provoke sleepiness and an upset stomach. But once you know the right dosage for your pet, there is no problem at all.

Carprofen and CBD Interaction

We always recommend consulting with your vet before introducing CBD and other medications to your pet.

Even though CBD remains one of the most effective alternative therapies, the combination of CBD and other medications can be beneficial as well. Let us explain.

CBD can act as a natural inhibitor or inducer in cases of interaction with other medications. It means, it can increase or decrease its medical effectiveness and medication side effects as well.

If you have prescribed Carprofen as a main anti-inflammation medication, there is a good chance CBD can replace it. Because of its anti-inflammatory properties, CBD can be a great natural solution for pets even with strong inflammation and pain. Without harmful side effects, your pet might recover faster and be back in its daily happy life.

However, if that is not the case, you might want to ask your vet if you can complement Carprofen with CBD therapy. If CBD will act as an inducer, then you might be prescribed to take less Carprofen and more of natural pet CBD oil.

In all, the harmful side effects of many medications are the main thing that shifts our attention to natural solutions, such a CBD. If you proceed with a safe dosage and under vet supervision, a Carprofen and CBD combination can be possible. However, we recommend that you always consult with your vet first.

If you have any questions we will be happy to answer them by email, [email protected], phone 1-888-898-9080, Facebook or Instagram or our contact us page!

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Which Dogs Should Not Receive CBD?

Continued research is essential to furthering our understanding of how CBD affects the canine body.

Cannabidiol (CBD) is one of over 90 cannabinoids produced by the Cannabis sativa plant and has great potential for therapeutic application in veterinary medicine. The 2018 Farm Bill legalized the regulated production and use of hemp and hemp products that contain less than 0.3% tetrahydrocannabinol (THC) in the United States, and since then, CBD products have become widely available and interest in using CBD to treat our pets is increasing. This is due to not only anecdotal reports, but also scientific evidence of beneficial behavioral and health effects, especially for such conditions as pain (particularly with arthritis), inflammation, anxiety, seizures, and immune system modulation in companion animals.

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Overall, CBD use in dogs appears to have a good safety profile and is at low risk for side effects. “Appears” is the key word here, however. Because cannabidiol and other hemp products were federally illegal until 2018, we are only now beginning to see the results of recent scientific studies conducted on these products.

It is known that dogs, like humans, have an endocannabinoid system (a complex cell signaling system); however, experts haven’t yet determined how it all works. Because we are in only the very early stages of understanding just how cannabinoid-based medications affect the canine body, we need to be cautious in administering CBD to our dogs. While we wait for the results of new and ongoing research, here are some key points to be aware of when considering CBD:

  • Currently, there are no veterinary drugs containing CBD that are approved by the United States Food & Drug Administration (FDA). CBD products are currently sold as nutritional supplements and “drug claims” about their use are strictly illegal.
  • There is little documented research, control, or regulation over CBD products. This can result in highly varying compositions, concentrations, and quality, even from one batch to the other of the same product. Because of this, consumers may not know what any individual product contains.
  • A recent study (“Cannabinoid, Terpene, and Heavy Metal Analysis of 29 Over-the-Counter Commercial Veterinary Hemp Supplements”, Vet Med (Auckl). 2020;11:45-55) by Cornell College of Veterinary Medicine and ElleVet Sciences, a manufacturer of pet CBD products, tested 29 CBD pet products. Label guarantees to the cannabinoid concentration contained in the supplement were present on 27 of the 29 products, however, only 10 of the 27 “were within 10% of the total cannabinoid concentrations of their label claim.” Several tested below their label claims of cannabinoid concentration, and two products were found not to contain any CBD at all. Heavy metal contamination was found in four of the products, with lead being the most prevalent contaminant (three products).
  • Owners and veterinarians considering the use of CBD need to be aware of the prevalence of low concentration products. Obtaining a certificate of analysis (COA) from a third party laboratory will enable correct calculation of dosage.
  • There is not yet any data available as to the effects of long-term administration of CBD to dogs. It is also not known if there is any cumulative effect.
  • Of particular concern is any potential interaction between CBD and other medications. Because CBD is metabolized by the cytochrome P450 family of enzymes, it can affect the metabolizing of the other medications in the system. In turn, this can alter the efficacy of these other drugs, either by enhancing their activity or inhibiting the desired activity. Studies with humans have demonstrated that this interaction has impacted drug concentrations in the blood. It has been determined that there is the potential for interaction in humans with the drugs warfarin, tacrolimus, theophylline, ketoconazole, and zonisamide. As these drugs are also used in dogs, it is possible that that there may be interactions in the canine body as well. Other medications that CBD may interfere with include antibiotics, antipsychotics, antidepressants, blood thinners, and any other drugs metabolized by P450 enzymes.
  • Scientific studies have shown that CBD can cause an increase in the liver enzyme alkaline phosphatase (ALP), but the significance of this is not yet known. CBD is thought to be able to enhance the effects of certain drugs. This may present an opportunity or need to reduce the dose of certain medications that are administered to a patient who is also being given CBD.
  • As NSAIDs, Tramadol, Gabapentin, and anti-anxiety drugs rely on P450 enzymes for metabolizing, approach the addition of CBD carefully.
  • When given with trazadone, CBD was found to inhibit the ability of trazodone to lower blood cortisol in a recent study by Morris et al (The Impact of Feeding Cannabidiol [CBD] Containing Treats on Canine Response to a Noise-Induced Fear Response Test, Front. Vet. Sci., 22 September 2020). This highlights the potential drug interactions associated with CBD and may support previous work that shows CBD to be a potent inhibitor of the cytochrome P450 family of enzymes.
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Continued research is essential to furthering our understanding of how CBD affects the canine body. As with any medication, consult your veterinarian before treating your dog with CBD.

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