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The cannabinoids produced in cannabis are structurally very similar to chemicals produced by the human body, suitably known as “endocannabinoids”. Endocannabinoids naturally bind to receptors in the endocannabinoid system [2] , and thus the cannabinoids from marijuana can influence this physiological system as well. The endocannabinoid system (ECS for short) is a regulatory system located throughout the nervous and immune systems, the skin, and more. Cannabinoids and endocannabinoids can either bind directly to receptors in this system (like THC) or influence them in indirect, but still profound ways of their own (CBD). By stimulating a response from these receptors, cannabinoids can mediate many important bodily functions.

Glaucoma is one of the most cited reasons for using medicinal cannabis. Dating back to the 1970s, research found that both cannabis and isolated THC reduced intraocular pressure, which is a main reason for the condition. Back then, using marijuana for treating glaucoma [9] generated a lot of interest as the other medications available all came with adverse side effects. However, it bears mentioning that conventional medications for glaucoma are now available that don’t have these drawbacks.

RESEARCH ON MEDICAL MARIJUANA

The ECS plays a role in such processes as: metabolism and appetite regulation, memory function, mood, sleep, immune function, and more. This opens up many potential therapeutic uses for cannabis.

One of the most talked about uses for medical cannabis is to reduce seizures in difficult-to-treat forms of epilepsy. In 2018, the US Food and Drug Administration (FDA) approved the use [6] of an oral cannabidiol (CBD) solution called Epidiolex for the treatment of two rare forms of childhood epilepsy, Lennox-Gastaut syndrome and Dravet syndrome. For these patients, CBD can significantly reduce seizure frequency, potentially stopping them from happening entirely.

Scientific data about using CBD for multiple sclerosis (MS) is still sparse, but early and very limited results are promising. A 2018 study [12] found cannabidiol (CBD) “reduces spasticity, pain, inflammation, fatigue, and depression”, which are the main contributing factors for immobility in MS sufferers. The study indicates that cannabis strains with a 1:1 or greater CBD:THC ratio are most effective for treating these symptoms.

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