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So what’re the differences between CBD, CBDA, CBGA and marijuana plants you’d buy at a dispensary? The main differences between CBD & CBDA are: CBD can be extracted from the flower and leaves of hemp, while CBDA is the raw, unheated precursor of CBD. Both are non-impairing, non-intoxicating and help support body and mind.

Cannabis and COVID: Key differences between CBD, CBDA and CBGA

New study finds cannabis compounds block coronavirus proteins

Ken Haddad , Digital Content Manager

GRANTHAM, ENGLAND – AUGUST 27: Hemp oil is tested for quality in the process department at British CBD oil producer Crop England on August 27, 2021 in Grantham, England. British CBD oil was founded in 2019 by Mike and Jackie Lamyman. The popularity of CBD oil from the cannabis family of plants has grown in recent years due to its health properties. (Chris Furlong, 2021 Getty Images)

A study published this week by researchers at Oregon State University found some hemp compounds have the ability to prevent the virus that causes COVID-19 from entering human cells.

Findings of the study led by Richard van Breemen, a researcher with Oregon State’s Global Hemp Innovation Center, College of Pharmacy and Linus Pauling Institute, were published this week in the Journal of Natural Products.

Hemp, known scientifically as cannabis sativa, is a source of fiber, food and animal feed, and multiple hemp extracts and compounds are added to cosmetics, body lotions, dietary supplements and food, van Breemen said.

“We identified several cannabinoid ligands and ranked them by affinity to the spike protein,” van Breemen said. “The two cannabinoids with the highest affinities for the spike protein were CBDA and CBGA, and they were confirmed to block infection.”

So what’re the differences between CBD, CBDA, CBGA and marijuana plants you’d buy at a dispensary?

CBD, an abbreviation for cannabidiol, doesn’t produce any psychoactive effects. It’s likely what you see at some pharmacies, health stores or dispensaries.

It’s a very versatile compound, which makes it ideal for oils, gummies, lotions, creams and other products. Hemp contains a lot of CBD.

But CBD is not the compound that was tested in the Oregon State study. CBD is activated in hemp plants from its original form — CBDA.

CBDA, known as cannabidiolic acid, is secreted in the stems, leaves and flowers of a cannabis plant. When the plant undergoes activation (a process with heat), the acid is removed from the CBDA, activating CBD.

They have similar compounds, but CBDA is not as versatile. It’s usually extracted by “juicing” plant material, and can be added to foods, drinks, or used in tinctures, concentrated herbal extracts.

But basically, CBDA is the raw form of CBD. And it’s not as easy to find. But you can buy it. (It has not been studied as much as CBD)

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CBGA, known as cannabigerolic acid, is considered the “mother cannabinoid,” because without it, there is no CBD, CBDA or THC.

CBGA compounds are similar to other cannabinoids, but it hasn’t been studied nearly as much as the others. It’s non-intoxicating. Enzymes called synthases are responsible for converting the CBGA into molecules such as THCA, the raw, unactivated molecule that converts to THC after heat is applied.

Again, you can find this in oils and tinctures online, but it’s harder to find and at times, pretty expensive, because it’s harder to extract.

What about smoking marijuana?

At this point, it doesn’t appear that just smoking marijuana, even a heavy CBD strain, will produce the effects reported in this study. We don’t have enough information to suggest it.

CBDA or CBGA products, like oils, offering these in their raw form, do not work the same in marijuana products, which usually include high levels of THC, the psychoactive compound that makes you high.

And before trying something new, do your research, talk to your doctor and make sure it’s something you should bring into your life. Check out Project CBD for some information on getting started.

Copyright 2022 by WDIV ClickOnDetroit – All rights reserved.

About the Author:
Ken Haddad

Ken Haddad is the digital content and audience manager for WDIV / ClickOnDetroit.com. He also authors the Morning Report Newsletter and various other newsletters. He’s been with WDIV since 2013. He enjoys suffering through Lions games on Sundays in the fall.

What is CBDA? Differences & Benefits of CBD vs CBDA – Healer

CBD, or cannabidiol, is a cannabinoid that can be extracted from the flower and leaves of hemp varieties of Cannabis sativa. CBDA is the raw, unheated precursor of CBD.

Both CBD and CBDA are non-impairing, non-intoxicating and help support body and mind. They are just two of over 100+ cannabinoids and other physiologically active constituents in Cannabis sativa.

Cannabidiol (CBD) is a well-known component of hemp with diverse health benefits. Many are surprised to learn that the hemp plant does not directly produce CBD. The plant actually produces cannabidiolic acid (CBDA) which converts to CBD slowly at room temperature, or rapidly when exposed to high temperatures.

CBD and CBDA share many physiologic properties, but also have some important differences:

  • CBDA is more easily absorbed (up to 11 times) when taken by mouth, compared to CBD. [1]
  • CBDA and CBD both have anti-inflammatory properties, but may act via different mechanisms in the body. For example, unlike CBD, CBDA has been shown to decrease the activity of the COX-2 enzyme, an enzyme responsible for increasing inflammation.[2]
  • CBDA may be more potent than CBD for some applications based on studies of rodent models of nausea [3], stress-induced anxiety [4], pain and inflammation, and seizures [5]. We don’t know if similar results translate to humans yet, but it is possible that CBDA may be more effective than CBD at lower doses.
  • CBDA is unlikely to mitigate the adverse effects of THC, a common usage of CBD. While many people appreciate the combined effects of CBD and THC, some find that CBD weakens the beneficial effects of THC and may prefer CBDA.
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Understanding The Benefits of CBDA

Most people are familiar with CBD oil, which is very popular these days for its health and wellness benefits. But there’s another lesser known cannabinoid called CBDA that is gaining attention from consumers and the scientific community as early findings show that even small amounts of CBDA can have significant beneficial physiological effects.

CBDA has many important differences to CBD that make it even more powerful, namely

  • CBDA is better absorbed (5-11 times better)[1]
  • CBDA acts more strongly in studies on rodents for inflammatory pain[3], nausea[4], and anxiety[5].
  • CBDA does not lower or diminish the benefits of THC like CBD.

Because high-quality human research on these cannabinoids is still emerging and there are still many unknowns, in this post we’ll share what you need to know about this CBDA oil.

CBDA Benefits:

  • Relieve pain and inflammation after physical activity*
  • Help with occasional sleeplessness*
  • Improve mood, promote resilience to stress and relieve irritability*
  • Promotes alertness and clear thinking*
  • Enhance performance and recovery from exercise*

*These statements have not been evaluated by the Food and Drug Administration.

What is CBDA oil?

Oils infused with CBDA are the best delivery method for taking CBDA. CBDA oil is generally concentrated and used as the active ingredient in cannabis tinctures, vaporizers, topicals, capsules, edibles and other products.

High-quality CBDA oils are harder to find because acidic cannabinoids are more difficult to extract and stabilize, but those currently available come in several forms: isolate, broad spectrum, full spectrum and Healer spectrum:

  • CBDA Isolates contain CBDA alone. All of the other beneficial plant components are removed using a chemical process. Since these highly processed formulas don’t absorb as well, nano-emulsifiers are added to boost their effectiveness, and the consumer typically requires higher amounts.
  • Broad Spectrum CBDA products contain CBDA along with some of the naturally occurring compounds from the hemp plant, without THC or THCa. These oils are also processed using chemical reactions to remove THC and THCA.
  • Full Spectrum CBDA products include the legally allowed trace amounts of THC and THCA (a maximum of 0.3% THC). While the term ‘full spectrum’ is meant to describe products that retain all of the beneficial plant compounds, many products labeled full spectrum actually only contain THC while others add in terpenes from other plants.
  • Healer Spectrum CBDA products are made using Healer’s patented nano-filtration technology to contain the full range of naturally occurring plant compounds including acidic and other minor cannabinoids, the legally allowed trace amounts of THCA and THC (less than 0.3%) , and the plant’s original terpenes, flavonoids and phytonutrients.
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What is the most effective way to take CBDA?

Placing CBDA oil drops under your tongue (sublingual administration) is the best way to ensure fast and efficient absorption and minimize delays associated with digestion. CBDA oil drops may be added to food or drinks, too. However, you may require a larger amount and it may take longer to feel the effects. CBDA oil drops can be applied directly to the skin as a topical or added to your favorite cream or beauty product.

How is CBDA different from CBD?

In many ways, CBDA works similarly to CBD by influencing the endocannabinoid system and other biological systems within our bodies. But, CBDA has many important differences that make it even more powerful, namely CBDA is better absorbed (5-11 times better)[1] and acts more strongly in the body regarding pain & inflammation after physical activity, symptoms of nausea[4], and worry[5].

You’ll see better results at lower dosages when using CBDA products (or whole plant hemp CBD products that contain CBDA) compared to pure or nearly-pure CBD isolate. If you have tried CBD without much success, don’t assume CBDA won’t help.

CBD or CBDA? Which product is best for me?

We recommend starting with Healer Hemp CBD, which contains mostly CBD and about 15% CBDA, along with the Healer Spectrum of naturally occurring minor cannabinoids, terpenes, flavonoids, and other important phytonutrients.

While the human research on both CBD and CBDA is still emerging, early findings show that even small amounts of CBDA, like those found in our CBD formula, can have significant physiologic effects.

However, you should start with our CBDA product if:

  • You want to try CBDA’s more powerful benefits or know you respond better to CBDA.
  • You’ve tried CBD in the past in moderate to high amounts (25-50mg) and have been unsatisfied with the results
  • You’re using THC and you don’t want your hemp product to decrease its effects

[1] Pellesi, L., et al. European Journal of Clinical Pharmacology 74.11 (2018): 1427-1436.

[2] Anderson, Lyndsey L., et al. Journal of natural products 82.11 (2019): 3047-3055.

[3] Rock, E. M., et al. Psychopharmacology 235.11 (2018): 3259-3271.

[4] Rock, E. M., et al. British Journal of Pharmacology 169.3 (2013): 685-69

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